Safety concerns over the use of intestinal permeation enhancers: A mini-review
نویسندگان
چکیده
منابع مشابه
Intestinal permeation enhancers for oral peptide delivery.
Intestinal permeation enhancers (PEs) are one of the most widely tested strategies to improve oral delivery of therapeutic peptides. This article assesses the intestinal permeation enhancement action of over 250 PEs that have been tested in intestinal delivery models. In depth analysis of pre-clinical data is presented for PEs as components of proprietary delivery systems that have progressed t...
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Per oral delivery of hydrophilic drugs is one of the most challenges in biopharmaceutical research. Hydrophilic drugs show low bioavailability following oral administration because of their poor intestinal permeation. In the last few years great interest has focused on search of different intestinal permeation enhancers for the oral delivery of BCS class iii drugs, small polar molecules, vaccin...
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Transdermal systems are non-invasive, convenient, and inexpensive and can be self-administered. They can provide sustained plasma concentration profile for long periods of time. The systems can greatly improve patient compliance through avoidance of first-past metabolism, improved bioavailability, reduction of systemic side effects and dosing schedule. In the past three decades, transdermal dru...
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ژورنال
عنوان ژورنال: Tissue Barriers
سال: 2016
ISSN: 2168-8370
DOI: 10.1080/21688370.2016.1176822